Document Type

Article

Publication Date

2011

Abstract

An approach based on mosquitoes carrying a conditional dominant lethal gene (release of insects carrying a dominant lethal, RIDL) is being developed to control the transmission of dengue viruses by vector population suppression. A transgenic strain, designated OX3604C, of the major dengue vector, Aedes aegypti, was engineered to have a repressible female-specific flightless phenotype. This strain circumvents the need for radiation-induced sterilization, allows genetic sexing resulting in male-only releases, and permits the release of eggs instead of adult mosquitoes. OX3604C males introduced weekly into large laboratory cages containing stable target mosquito populations at initial ratios of 8.5-10:1 OX3604C:target eliminated the populations within 10-20 weeks. These data support the further testing of this strain in contained or confined field trials to evaluate mating competitiveness and environmental and other effects. Successful completion of the field trials should facilitate incorporation of this approach into areawide dengue control or elimination efforts as a component of an integrated vector management strategy.

Digital Object Identifier (DOI)

10.1073/pnas.1019295108

Publication Title

Proceedings of the National Academy of Sciences of the United States of America

Volume

108

Issue

12

Comments

© the authors. Original published version available at https://doi.org/10.1073/pnas.1019295108.

Wise De Valdez, M., Nimmo, D., et al. (2011). Genetic Elimination of Dengue Vector Mosquitoes. Proceedings of the National Academy of Sciences of the United States of America, 108(12), 4772-4775.

Included in

Biology Commons

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.